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Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy

Their commitment is primarily governed by the mutually inhibitory master regulators retinoic acid-related orphan receptor gamma-t (RORt) (driving the Th17 lineage) and forkhead box P3 (Foxp3) (orchestrating the Treg program), within cytokine milieus that favor either pro-inflammatory (e.g., IL-6, IL-23) or anti-inflammatory (e.g., TGF-, IL-2) outcomes ( Figure 1 )

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Asthenozoospermics-Astheno [74 cases]: This study group consists of isolated asthenozoospermic men whose infertility is determined mainly by less than normal levels for sperm motility ( 20 106 sperm/ml)

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